Browsing Experimentally Confirmed database

Result: Your query found 86 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
abeM
  • BacMet ID: BAC0001
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: H-coupled multidrug efflux pump. Confers resistance to Antibiotics such as quinolones and aminoglycosides and antibacterial biocides such as dyes, QACs.
  • Length (amino acid): 448
  • Reference: Su et al. 2005; Pubmed- 16189122

    		• Similar resistance genes in 'BacMet Predicted database'
    abeS
  • BacMet ID: BAC0002
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein abeS. It can confer resistance to antibiotics such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin and dyes, QACs etc.
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2009; Pubmed- 19770280

    		• Similar resistance genes in 'BacMet Predicted database'
    acrE/envC
  • BacMet ID: BAC0009
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine]
  • Description: Acriflavine resistance protein E; May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability. It can confer resistance to novomycin.
  • Length (amino acid): 385
  • Reference: Klein et al. 1991; Pubmed- 1720861, Ma et al. 1993; Pubmed- 8407802, Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    acrF/envD
  • BacMet ID: BAC0010
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine]
  • Description: Acriflavine resistance protein F; Involved in cell envelope formation. It is produced in extremely low amounts.
  • Length (amino acid): 1034
  • Reference: Klein et al. 1991; Pubmed- 1720861, Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    adeA
  • BacMet ID: BAC0471
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: AdeA membrane fusion protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 396
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeB
  • BacMet ID: BAC0472
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergise, Wex-cide-128.
  • Description: AdeB RND protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 1035
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeC
  • BacMet ID: BAC0473
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: AdeC outer membrane protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 465
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeI
  • BacMet ID: BAC0017
  • Code for: efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Rhodamine 123 [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Synergize [class: QAC-Glutaraldehyde], Virkon S [class: Peroxysulfate], Wex-cide-128 [class: Phenyl]
  • Description: Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detergents such as sodium dodecyl sulfate.
  • Length (amino acid): 416
  • Reference: Damier-Piolle et al. 2008; Pubmed- 18086852, Rajamohan et al. 2010; Pubmed- 20008046

    		• Similar resistance genes in 'BacMet Predicted database'
    adeT1
  • BacMet ID: BAC0478
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni AC0037
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, tetracycline etc.
  • Length (amino acid): 304
  • Reference: Srinivasan et al. 2011; Pubmed- 21212056

    		• Similar resistance genes in 'BacMet Predicted database'
    adeT2
  • BacMet ID: BAC0479
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, ciprofloxacin, erythromycin etc.
  • Length (amino acid): 238
  • Reference: Srinivasan et al. 2011; Pubmed- 21212056

    		• Similar resistance genes in 'BacMet Predicted database'
    amvA
  • BacMet ID: BAC0025
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: MFS efflux pump, AmvA (AedF). Mediates drugs, dyes, detergents, antibiotic and disinfectant resistance
  • Length (amino acid): 492
  • Reference: Rajamohan et al. 2010; Pubmed- 20573661

    		• Similar resistance genes in 'BacMet Predicted database'
    bepC
  • BacMet ID: BAC0042
  • Code for: Efflux
  • Family: RND superfamily, OMP/TolC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host. Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. It can form a tripartite pump with BepD and BepE or with BepF and BepG.
  • Length (amino acid): 456
  • Reference: Posada et al. 2007; Pubmed- 17088356

    		• Similar resistance genes in 'BacMet Predicted database'
    blt
  • BacMet ID: BAC0050
  • Code for: Efflux
  • Family: MFS Superfamily (TCR/tet family)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics.
  • Length (amino acid): 400
  • Reference: Ahmed et al. 1995; Pubmed- 7608059

    		• Similar resistance genes in 'BacMet Predicted database'
    bmr
  • BacMet ID: BAC0053
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics.
  • Length (amino acid): 389
  • Reference: Neyfakh et al. 1991; Pubmed- 1675788

    		• Similar resistance genes in 'BacMet Predicted database'
    cpxA
  • BacMet ID: BAC0532
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Sensor protein of stress-related two-component regulatory system of CpxAR. It has role in oxidative stress tolerance. It has a regulatory role on MDR efflux pumps. It can confer resistance to cefepime, cefotaxime, ceftazidime and chloramphenicol which possibly are the preferred substrates of the resistance determinants for e.g. efflux pumps perhaps regulated by the Cpx regulon.
  • Length (amino acid): 457
  • Reference: Srinivasan et al. 2012; Pubmed- 22496764

    		• Similar resistance genes in 'BacMet Predicted database'
    cpxR
  • BacMet ID: BAC0533
  • Code for: Regulator
  • Family: Contains 1 response regulator domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Response regulator of stress-related two-component regulatory system. It has role in oxidative stress tolerance. It has a regulatory role on MDR efflux pumps. It can confer resistance to cefepime, cefotaxime, ceftazidime and chloramphenicol which possibly are the preferred substrates of the resistance determinants for e.g. efflux pumps perhaps regulated by the Cpx regulon.
  • Length (amino acid): 232
  • Reference: Srinivasan et al. 2012; Pubmed- 22496764

    		• Similar resistance genes in 'BacMet Predicted database'
    emeA
  • BacMet ID: BAC0141
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Enterococcus faecalis (Streptococcus faecalis)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux pump emeA
  • Length (amino acid): 393
  • Reference: Lee et al. 2003 ; Pubmed- 12576692

    		• Similar resistance genes in 'BacMet Predicted database'
    emmdR
  • BacMet ID: BAC0146
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterobacter cloacae
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene]
  • Description: MATE efflux family protein; EmmdR is an H+-drug antiporter but not a Na+ driven efflux pump
  • Length (amino acid): 462
  • Reference: He et al. 2011; Pubmed- 21822795

    		• Similar resistance genes in 'BacMet Predicted database'
    emrD
  • BacMet ID: BAC0149
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Multidrug resistance pump that participates in a low energy shock adaptative response
  • Length (amino acid): 394
  • Reference: Naroditskaya et al. 1993; Pubmed- 8240355, Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    emrD-3
  • BacMet ID: BAC0534
  • Code for: Efflux
  • Family: MFS superfamiy, Bcr/CflA subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae O395
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: It is an intrinsic membrane protein. Multidrug resistance protein D. EmrD-3-mediated efflux is potentiated by a proton gradient across the membrane. It can confer resistance to antibiotics such as linezolid, rifampin, minocycline etc.
  • Length (amino acid): 379
  • Reference: Smith et al. 2009; Pubmed- 19876617

    		• Similar resistance genes in 'BacMet Predicted database'
    emrE/mvrC
  • BacMet ID: BAC0150
  • Code for: Efflux/Membrane protein
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (Strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: It codes for a membrane protein emrE/MvrC, exhibits resistance to methyl viologen by reducing permeability. Overexoression of MvrC protein induces or activates the MvrA protein, which reduces the toxic species produced by metyl viologen. It doesn’t confer resistance to plumbagin dye. It expels positively charged hydrophobic drugs across the inner membrane of E. coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. It is involved in the resistance of E. coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP+) and benzylkonium.
  • Length (amino acid): 110
  • Reference: Morimyo et al. 1992; Pubmed- 1320256, Yerushalmi et al. 1995; Pubmed- 7896833, Yerushalmi et al. 2000; Pubmed- 10681497, Rotem et al. 2004; Pumed- 15371426

    		• Similar resistance genes in 'BacMet Predicted database'
    emrK
  • BacMet ID: BAC0151
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein; overexpression resistance to deoxycholate
  • Length (amino acid): 387
  • Reference: Tanabe et al. 1997; Pubmed- 12501312, Kato et al. 2000; Pubmed- 10923791

    		• Similar resistance genes in 'BacMet Predicted database'
    hmrM
  • BacMet ID: BAC0189
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump that functions as a Na+/drug antiporter. Confers resistance to norfloxacin, Acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate
  • Length (amino acid): 464
  • Reference: Xu et al. 2003; Pubmed- 14695443

    		• Similar resistance genes in 'BacMet Predicted database'
    hsmR
  • BacMet ID: BAC0192
  • Code for: Efflux
  • Family: SMR superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Small multidrug export protein HsmR
  • Length (amino acid): 112
  • Reference: Ninio et al. 2003; Pubmed- 12551892

    		• Similar resistance genes in 'BacMet Predicted database'
    kdeA
  • BacMet ID: BAC0491
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae (strain MGH 78578)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: It can confer resistance to antibiotics such as chloramphenicol, Kanamycin, norfloxacin, puromycin, daunomycin etc.
  • Length (amino acid): 410
  • Reference: Ping et al. 2007; Pubmed- 17917272

    		• Similar resistance genes in 'BacMet Predicted database'
    kexD
  • BacMet ID: BAC0492
  • Code for: Effflux
  • Family: Restriction Nodulation Division (RND) superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae
  • Location: Chromosome
  • Compound: Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: KexD was shown to function with AcrAEc and TolC from E. coli and AcrAKp and KocC from K. pneumoniae, like AcrD from E. coli
  • Length (amino acid): 1038
  • Reference: Ogawa et al. 2012; Pubmed- 22391093

    		• Similar resistance genes in 'BacMet Predicted database'
    kmrA
  • BacMet ID: BAC0493
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Hoechst 33342 [class: Bisbenzimide], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: It can confer resistance to Antibiotics such as kanamycin, gentamycin, erythromycin etc.
  • Length (amino acid): 499
  • Reference: Ogawa et al. 2006; Pubmed- 16508165

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnE
  • BacMet ID: BAC0476
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin.
  • Length (amino acid): 120
  • Reference: Srinivasan et al. 2013; Pubmed- 23836167

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnF
  • BacMet ID: BAC0477
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2013; Pubmed- 23836167

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnO
  • BacMet ID: BAC0529
  • Code for: Porin
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Nitrite (NaNo2) [class: Nitrites]
  • Description: KpnO codes for a outer membrane porin. kpnO mediates antibiotic resistance via efflux mechanism and contributes towards disinfectant tolerance. It has a role in oxidative stress tolerance and nitrostative stress tolernace. KpnO also contributes to growth and gastrointestinal stress tolerance in K. pneumoniae.
  • Length (amino acid): 365
  • Reference: Srinivasan et al. 2012; Pubmed- 22848515

    		• Similar resistance genes in 'BacMet Predicted database'
    lmrS
  • BacMet ID: BAC0535
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus subsp. aureus COL
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: LmrS is an efflux protein capable of extruding multiple and structurally unrelated antimicrobial compounds. It can confer resistance to antobiotics such as linezolid, trimethoprim, chloramphenicol etc.
  • Length (amino acid): 480
  • Reference: Floyd et al 2010; Pubmed- 20855745

    		• Similar resistance genes in 'BacMet Predicted database'
    mdeA
  • BacMet ID: BAC0207
  • Code for: Enzyme
  • Family: Trans-sulfuration enzymes family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene]
  • Description: Methionine gamma-lyase (MdeA)
  • Length (amino acid): 398
  • Reference: Huang et al. 2004; Pubmed- 14982783, Yamada et al. 2006; Pubmed- 16595922, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    mdfA/cmr
  • BacMet ID: BAC0208
  • Code for: Effux
  • Family: Major facilitator Superfamily (MdfA family)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, E. coli (Strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Hydroxide (NaOH) [class: Base], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug transporter MdfA, Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzylkonium, rifampicin, tetracycline, puromycin, and to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. OverExpression results in isopropyl-beta-D-thiogalactopyranoside (IPTG) exclusion and spectinomycin sensitivity. Transport of neutral substrates is electrogenic, whereas transport of cationic substrates is electroneutral. In addition to its role in multidrug resistance, confers extreme alkaline pH resistance, allowing the growth under conditions that are close to those used normally by alkaliphiles. This activity requires Na+ or K+; also known as Chloramphenicol resistance pump Cmr
  • Length (amino acid): 410
  • Reference: Edgar et al. 1997; Pubmed- 9079913, Nishino et al. 2001; Pubmed- 11566977, Sulavik et al 2001; Pubmed- 11257026

    		• Similar resistance genes in 'BacMet Predicted database'
    mdrL/yfmO
  • BacMet ID: BAC0209
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Listeria monocytogenes
  • Location: Chromosome
  • Compound: Zinc (Zn), Cobalt (Cobalt), Chromium (Cr), Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance transporter mdrL/YfmO. It can confer resistance to antibiotics such as erythromycin, josamycin, clindamycin etc.
  • Length (amino acid): 397
  • Reference: Mata et al. 2000; Pubmed- 10856655

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtE/yhiU
  • BacMet ID: BAC0213
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtE; Part of a multidrug resistance efflux system (mdtEF-TolC) that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC. It has a role in biofilm formation of E. coli K12.
  • Length (amino acid): 385
  • Reference: Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtF/yhiV
  • BacMet ID: BAC0214
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtF; Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC.
  • Length (amino acid): 1037
  • Reference: Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtK/ydhE
  • BacMet ID: BAC0218
  • Code for: Efflux
  • Family: MATE family, MdtK subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Multidrug resistance protein MdtK; It functions as a Na+/drug antiporter. Confers resistance to many drugs such as fluoroquinolones (norfloxacin, ciprofloxacin, enoxacin), tetraphenylphosphonium ion (TPP), deoxycholate, doxorubicin, trimethoprim, chloramphenicol, fosfomycin, Acriflavine, ethidium bromide and benzylkonium
  • Length (amino acid): 457
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtM/yjiO
  • BacMet ID: BAC0219
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtM; Confers resistance to Acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP, tetraphenylarsonium chloride ; part of a tripartite efflux system composed of MdtN, MdtO and MdtP
  • Length (amino acid): 410
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtN/yjcR
  • BacMet ID: BAC0220
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtN; Involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP
  • Length (amino acid): 343
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    mepA
  • BacMet ID: BAC0221
  • Code for: Efflux
  • Family: Multi antimicrobial extrusion (MATE) family (MepA subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Chromosome
  • Compound: Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentadiamine [class: Diamidine], Trimethylamine-diphenylhexatriene (TMA-DPH) [class: Diphenylhexatriene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene]
  • Description: Multidrug Export protein, Multidrug resistance efflux protein By similarity. Contributes to resistance to the glycylcycline antibiotic tigecycline, ciprofloxacin, norfloxacin etc.
  • Length (amino acid): 451
  • Reference: McAleese et al. 2005; Pubmed- 15855508, Kaatz et al. 2005; Pubmed- 15855507, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    mmR
  • BacMet ID: BAC0249
  • Code for: Efflux
  • Family: SMR family, mmr subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene]
  • Description: Multidrug efflux pump mmR. Confers resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y.
  • Length (amino acid): 107
  • Reference: Rossi et al. 1998; Pubmed- 9811672

    		• Similar resistance genes in 'BacMet Predicted database'
    norA
  • BacMet ID: BAC0282
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine] , Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quinolone resistance protein norA, Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones.
  • Length (amino acid): 388
  • Reference: Yoshida et al. 1990; Pubmed- 2174864, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    norB
  • BacMet ID: BAC0283
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus (strain MW2)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quinolone resistance protein norB, Multidrug efflux pump that acts independently of norA and is one of the factors that confers resistance against diverse quinolones and chemical compounds By similarity. Can facilitate bacterial survival in vivo when overexpressed in an abscess and may contribute to the relative resistance of staphylococcal abscesses to antimicrobial therapy
  • Length (amino acid): 463
  • Reference: Ding et al. 2008; Pubmed- 18723624

    		• Similar resistance genes in 'BacMet Predicted database'
    norM/pmpM
  • BacMet ID: BAC0284
  • Code for: Efflux
  • Family: Multi antimicrobial extrusion (MATE) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, N. gonorrhoeae, N. meningitidis, Burkholderia vietnamiensis
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein NorM, inner cell-membrane, Multidrug efflux pump. Confers probably resistance to the cationic peptide polymyxin B (PMB).
  • Length (amino acid): 462
  • Reference: Fehlner-Gardiner et al. 2002; Pubmed- 1239904

    		• Similar resistance genes in 'BacMet Predicted database'
    oqxA
  • BacMet ID: BAC0294
  • Code for: Enzyme
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid p0LA52 (E. coli), Plasmid pGDGK3 (Klebsiella pneumoniae)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Clorine Dioxide (ClO2) [class: Halogens], Triclosan [class: Phenolic compounds], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine]
  • Description: RND family multidrug efflux permease oqxA; part of oqxAB efflux system, can co-select antibiotics such as Chloramphenicol, Ciprofloxacin, nofloxacin, trimethoprim etc. oqxAB efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli.
  • Length (amino acid): 391
  • Reference: Hansen et al. 2007; Pubmed- 17526501

    		• Similar resistance genes in 'BacMet Predicted database'
    oqxB
  • BacMet ID: BAC0295
  • Code for: Enzyme
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pOLA52 (E. coli),
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Clorine Dioxide (ClO2) [class: Halogens], Triclosan [class: Phenolic compounds], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine]
  • Description: RND family multidrug efflux permease oqxB; part of the oqxAB efflux system; can co-select antibiotics such as Chloramphenicol, Ciprofloxacin, nofloxacin, trimethoprim etc. oqxAB efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli.
  • Length (amino acid): 1050
  • Reference: Hansen et al. 2007; Pubmed- 17526501

    		• Similar resistance genes in 'BacMet Predicted database'
    phoB
  • BacMet ID: BAC0530
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of the two-component regulatory system PhoBR. It regulates kpnO in K. pneumoniae. It has a role in role in capsule production and bacterial growth in K. pneumoniae. It has no role in oxidative stress tolerance and nitrostative stress tolernace, but in gastrointestinal like challenges. (NB: THIS GENE IS MORE LIKELY TO BE 'PhoP' THOUGH AUTHORS MENTIONED IT AS 'PhoB'. THE SYSTEM MIGHT BE 'PhoPQ' INSTEAD OF 'PhoBR'.)
  • Length (amino acid): 237
  • Reference: Srinivasan et al. 2012; Pubmed- 22848515

    		• Similar resistance genes in 'BacMet Predicted database'
    phoR
  • BacMet ID: BAC0531
  • Code for: Regulator
  • Family: Contains 1 response regulator domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of the two-component regulatory system PhoBR. It regulates kpnO in K. pneumoniae. It has a role in role in capsule production and bacterial growth in K. pneumoniae. It has no role in oxidative stress tolerance and nitrostative stress tolernace, but in gastrointestinal like challenges.
  • Length (amino acid): 488
  • Reference: Srinivasan et al. 2012; Pubmed- 22848515

    		• Similar resistance genes in 'BacMet Predicted database'
    pmpM
  • BacMet ID: BAC0313
  • Code for: Efflux
  • Family: Member of the MATE family of transporters
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Multidrug resistance protein PmpM, Multidrug efflux pump that functions as an H+/drug antiporter. Confers resistance to benzylkonium chloride (BAC), fluoroquinolones, ethidium bromide, Acriflavine and tetraphenylphosphonium chloride.
  • Length (amino acid): 477
  • Reference: He et al. 2004; Pubmed- 14679249

    		• Similar resistance genes in 'BacMet Predicted database'
    qacA
  • BacMet ID: BAC0319
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Plasmid VRSAp, pSK1 (S. Aureus)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene], Quinaldine red [class: Quinolines], Rhodamine 6G [class: Xanthene], Safranin O [class: Azin], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Alexidine [class: Biguanides], Amicarbalide [class: Diamidine], Pentamidine [class: Diamidine], Hexamidine [class: Diamidine], Propamidine [class: Diamidine], Diamidinodiphenylamine [class: Diamidine], Dibrompropamidine [class: Diamidine], 1a-62/JC-1-127 [class: Guanylhydrazones], 1i-39/JC-1-134 [class: Guanylhydrazones], Stilbamidine [class: Diamidine], Phenamidine [class: Diamidine], Diminazene [class: Diamidine]
  • Description: Antiseptic resistnce gene qacA; Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines. qacA and qacB are different in sequence similarities by just by 7 nucleotides.
  • Length (amino acid): 514
  • Reference: Tennent et al 1989; Pubmed- 2778425, Rouch et al. 1990; Pubmed- 2089219, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814

    		• Similar resistance genes in 'BacMet Predicted database'
    qacB
  • BacMet ID: BAC0320
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Plasmid pTZ2162 (S. Aureus)
  • Compound: Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine], Amicarbalide [class: Diamidine], Hexamidine [class: Diamidine], Stilbamidine [class: Diamidine], 1i-39/JC-1-134 [class: Guanylhydrazones], 1a-62/JC-1-127 [class: Guanylhydrazones]
  • Description: Antiseptic efflux pump qacB. qacA and qacB are different in sequence similarities by just by 7 nucleotides.
  • Length (amino acid): 514
  • Reference: Alam et al. (2003), Pubmed- 12820795, Nakaminami, H. et al. (2008); Littlejon et al. 1992; Pubmed- 1526458, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814

    		• Similar resistance genes in 'BacMet Predicted database'
    qacC/qacD/smr
  • BacMet ID: BAC0321
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pTZ20, pWBG32, pTZ22, pKH8
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quaternary ammonium compound-resistance protein QacC (also called as QacD or smr); Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide. It confers resistance to toxic organic cations via proton-dependent export.
  • Length (amino acid): 107
  • Reference: Paulsen et al. 1995; Pubmed- 7751293, Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    qacE
  • BacMet ID: BAC0322
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Escherichia coli, K. pneumoniae, Pseudomonas aeruginosa
  • Location: Plasmid IncP-beta R751 (E. coli), Plasmid IncP-beta R751 (Enterobacter aerogenes)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quaternary ammonium compound-resistance protein qacE, Multidrug exporter. It is implicated for the resistance to bacteriocidal quaternary ammonium compounds.
  • Length (amino acid): 110
  • Reference: Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    qacEdelta1
  • BacMet ID: BAC0323
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Both gram +ve and -ve , Staphylococcus aureus, E. faecalis, P .aeruginosa
  • Location: Plasmid Rms149, In786, R388-R151 hybrid , pOZ176 , pKM0509, R1033, pKLC102, pLQ1001
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein QacEdelta 1. It can confer resistance to antibiotics as well such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin etc.
  • Length (amino acid): 115
  • Reference: Kazama et al. 1999; Pubmed- 10339831, Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    qacF
  • BacMet ID: BAC0324
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, E. aerogenes, E. cloacae
  • Location: Plasmid pIP833 (E. aerogenes)
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quaternary ammonium compound-resistance protein qacF, Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds
  • Length (amino acid): 110
  • Reference: Ploy et al. 1998; Pubmed- 9756755

    		• Similar resistance genes in 'BacMet Predicted database'
    qacG
  • BacMet ID: BAC0325
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: both gram +ve (s. aureus) and gram -ve (p.aeruginosa, A. salmonicida)
  • Location: Plasmid pST94 (Staphylococcus spp.)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine]
  • Description: Quaternary ammonium compound-resistance protein qacG, Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds
  • Length (amino acid): 107
  • Reference: Heir et al. 1997; Pubmed- 10196743

    		• Similar resistance genes in 'BacMet Predicted database'
    qacH/qacI
  • BacMet ID: BAC0326
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: only gram +ve, Staphylococcus aureus
  • Location: Plasmid pST2H6 ( Staphylococcus saprophyticus)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine]
  • Description: Quaternary ammonium compound-resistance protein qacH (also known as qacI), Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds.
  • Length (amino acid): 107
  • Reference: Heir et al. 1998; Pubmed- 9631545

    		• Similar resistance genes in 'BacMet Predicted database'
    qacJ
  • BacMet ID: BAC0327
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: only gram +ve, Staphylococcus spp.
  • Location: Plasmid pNVH01(S. aureus)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux protein QacJ
  • Length (amino acid): 107
  • Reference: Bjorland et al. 2003; Pubmed- 14506007

    		• Similar resistance genes in 'BacMet Predicted database'
    qacR
  • BacMet ID: BAC0328
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pSK1 (S. aureus)
  • Compound: Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine]
  • Description: HTH-type transcriptional regulator QacR, Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
  • Length (amino acid): 188
  • Reference: Grkovic et al. 1998; Pubmed- 9660841

    		• Similar resistance genes in 'BacMet Predicted database'
    qacZ
  • BacMet ID: BAC0329
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus faecalis (strain ATCC 700802 / V583)
  • Location: Plasmid pTEF1
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance transporter qacZ; qacZ gene in tolerance to the quaternary ammonium compound benzylkonium chloride, but not ethidium bromide or chlorhexidine.
  • Length (amino acid): 107
  • Reference: Braga et al. 2011: Pubmed- 21147826

    		• Similar resistance genes in 'BacMet Predicted database'
    ruvB
  • BacMet ID: BAC0293
  • Code for: Enzyme
  • Family: Malic enzymes family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas corrugata 28
  • Location: Chromosome
  • Compound: Chromium (Cr), Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dodine [class: Acetate], 2-nitroimidazole [class: imidazole]
  • Description: It is a fragment of ruvB gene product. It is a oxidoreductase from malic enzyme family.
  • Length (amino acid): 379
  • Reference: Decorosi et al. 2009; Pubmed- 19768364

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeA
  • BacMet ID: BAC0336
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Legionella longbeachae D-4968
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], n-hexane [class: Alkane], Chlorhexidine [class: Biguanides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance secretion protein SdeA; part of the sdeAB-tolC efflux system
  • Length (amino acid): 336
  • Reference: Maseda et al. 2009; Pubmed- 19752278, Kumar et al. 2002; Pubmed- 12356807, Kumar et al. 2005; Pubmed- 15793131, Begic et al. 2008; Pubmed- 18227249

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeB
  • BacMet ID: BAC0337
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens subsp. marcescens
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], n-hexane [class: Alkane], Chlorhexidine [class: Biguanides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux protein SdeB; part of the sdeAB-tolC efflux system
  • Length (amino acid): 1047
  • Reference: Maseda et al. 2009; Pubmed- 19752278, Kumar et al. 2005; Pubmed- 15793131, Begic et al. 2008; Pubmed- 18227249

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeX
  • BacMet ID: BAC0338
  • Code for: Efflux
  • Family: RND superfmaily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Serratia marcescens
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug efflux pump SdeX 
  • Length (amino acid): 393
  • Reference: Chen et al. 2003 ; Pubmed- 12837741

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeY
  • BacMet ID: BAC0339
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Serratia marcescens
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug efflux pump SdeY
  • Length (amino acid): 1051
  • Reference: Chen et al. 2003 ; Pubmed- 12837741

    		• Similar resistance genes in 'BacMet Predicted database'
    sepA
  • BacMet ID: BAC0340
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine]
  • Description: Multidrug resistance efflux pump sepA; Involved in multidrug efflux. Confers low level resistance to drugs such as Acriflavine, benzylkonium chloride (BAC), chlorhexidine gluconate and ethidium bromide
  • Length (amino acid): 382
  • Reference: Narui et al. 2002; Pubmed- 12499635

    		• Similar resistance genes in 'BacMet Predicted database'
    smfY
  • BacMet ID: BAC0363
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux pump SmfY
  • Length (amino acid): 490
  • Reference: Shahcheraghi et al. 2007; Pubmed- 17409524

    		• Similar resistance genes in 'BacMet Predicted database'
    smrA
  • BacMet ID: BAC0364
  • Code for: Efflux
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine]
  • Description: ABC-type multidrug efflux pump protein SmrA
  • Length (amino acid): 610
  • Reference: Al-Hamad et al. 2009; Pubmed- 19643774

    		• Similar resistance genes in 'BacMet Predicted database'
    smvA/emrB
  • BacMet ID: BAC0367
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Chromosome
  • Compound: Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Methyl viologen resistance protein SmvA, Major efflux pump for Acriflavine and other quaternary ammonium compounds (QACs). Also required for resistance to methyl viologen, Mutants show increased sensitivity to methyl viologen and Acriflavine.
  • Length (amino acid): 495
  • Reference: Santiviago et al. 2002; Pubmed- 12410826, Hongo et al. 1994; Pubmed- 7926834, Ogawa et al. 2006; Pubmed- 16508165

    		• Similar resistance genes in 'BacMet Predicted database'
    sugE
  • BacMet ID: BAC0378
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family (SugE subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: only gram -ve, Escherichia coli
  • Location: Plasmid IncN p541 (Escherichia coli), Plasmid pIW759 (Salmonella typhimurium)
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], and Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Quaternary ammonium compound-resistance protein sugE, Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; Unlike the other members of the SMR family, SugE exhibits a narrow specificity for a very specific class of compounds.
  • Length (amino acid): 105
  • Reference: Chung et al. 2002; Pubmed- 11948170, He et al. 2011; Pubmed- 21576447

    		• Similar resistance genes in 'BacMet Predicted database'
    tehA
  • BacMet ID: BAC0384
  • Code for: Membrane Transporter
  • Family: Tellurite-resistance/dicarboxylate transporter (TDT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tellurium (Te), Proflavin [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat]
  • Description: Tellurite resistance protein TehA; The gene encodes an integral membrane protein. Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance, otherwise phenotypically silent
  • Length (amino acid): 330
  • Reference: Walter et al 1991; Pubmed- 2060788, Taylor et al. 1994; Pubmed- 8169225, Turner et al. 1997; Pubmed- 9021204

    		• Similar resistance genes in 'BacMet Predicted database'
    tolC
  • BacMet ID: BAC0393
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Taurodeoxycholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Proflavin [class: Acridine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 6G [class: Xanthene], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Plumbagin [class: Naphthoquinone]
  • Description: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria. Required for acrAB, mar efflux pumps to act as multidrug efflux pump.
  • Length (amino acid): 493
  • Reference: Hackett et al. 1983; Pubmed- 6312426, Fralick et al. 1996; Pubmed- 8824631, Sulavik et al. 2001; Pubmed- 11257026

    		• Similar resistance genes in 'BacMet Predicted database'
    vcaM
  • BacMet ID: BAC0417
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acridine Orange [class: Acridine]
  • Description: ABC transporter, ATP-binding protein VcaM; Inner membrane protein
  • Length (amino acid): 619
  • Reference: Huda et al. 2003; Pubmed- 12878498

    		• Similar resistance genes in 'BacMet Predicted database'
    vcrM
  • BacMet ID: BAC0423
  • Code for: Efflux
  • Family: MATE family, DinF-subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae non-O1
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine]
  • Description: A Na+/drug antiporter-type multidrug efflux pump vcrM
  • Length (amino acid): 445
  • Reference: Huda et al. 2002; Pubmed- 12906102

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeA
  • BacMet ID: BAC0429
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Membrane fusion protein VmeA
  • Length (amino acid): 379
  • Reference: Matsuo et al. 2007; Pubmed- 18048926

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeB
  • BacMet ID: BAC0430
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Inner membrane protein VmeB
  • Length (amino acid): 1053
  • Reference: Matsuo et al. 2007; Pubmed- 18048926

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeC
  • BacMet ID: BAC0510
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide]
  • Description: VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 368
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeD
  • BacMet ID: BAC0511
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide]
  • Description: VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 1040
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeG
  • BacMet ID: BAC0517
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 343
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeH
  • BacMet ID: BAC0518
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 361
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeI
  • BacMet ID: BAC0519
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 1033
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeT
  • BacMet ID: BAC0524
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 361
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeU
  • BacMet ID: BAC0525
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 353
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeV
  • BacMet ID: BAC0526
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 1019
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmrA
  • BacMet ID: BAC0431
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Na+-coupled multidrug efflux pump VmrA; confers resistance to cationic drugs (4',6'-diamidino-2-phenylindole (DAPI), Tetraphenylphosphonium (TPP), Acriflavine, ethidium)
  • Length (amino acid): 447
  • Reference: Chen et al. 2002; Pubmed- 11751837

    		• Similar resistance genes in 'BacMet Predicted database'
    vpoC
  • BacMet ID: BAC0516
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid]
  • Description: Homologue of E. coli TolC outer membrane protein, vpoC.
  • Length (amino acid): 442
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
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